11 unique hats (plus Suave gambler hat if Wild Wasteland trait is selected).
No unique heavy armor item (except one worn by Legate Lanius in the ending quests).
So this list includes the maximum number of unique items with the reservation that I never end up collecting them all as I often prefer them worn by the original wearer. However, many are worn by friendly NPCs and require reverse pickpocketing or killing NPCs to collect. There are a range of unique and faction armour and clothing items to collect.
Collect all 31 moddable weapons and the 48 mods.
Depending on faction choices, players may want to exclude Big Boomer, Figaro, La Longue Carabine, Liberator and Recompense of the Fallen from the collection as these are owned by intially friendly NPCs.
I exclude Blade of the East from the above count because it is only found in the ending quests.
At a Loss for Words is very difficult to achieve with a high Speech skill.
Friendly Help requires the Mysterious Stranger or Miss Fortune perk.
Dine and Dash and Devourer of Nations require the Cannibal perk.
Complete all 37 non-recurring Other challenges with possible exceptions:.
Complete all 17 non-recurring Damage challenges.
Super Mutant Massacre requires careful hunting of respawn areas to fully complete.
Demise of the Machines requires Old World Blues or careful hunting of respawn areas such as New Vegas Steel.
Complete all 10 non-recurring Kill challenges.
It's a good idea to complete Bitter Springs Infirmary Blues, Climb Ev'ry Mountain and No, Not Much all before I Forgot to Remember to Forget.
Don't talk to Boxcars in Nipton until you're completing Wheel of Fortune.
Powder Ganger quests for Eddie at NCRCF should be completed before Ghost Town Gunfight (if chosen above).
Aba Daba Honeymoon needs to be completed before killing Motor-Runner for Colonel Hsu.
Quests that are sensitive to the order of other quests include:
Bugged unmarked quests: Poor Meat Never Makes Good Soup, Wind-Brahmin Wrangler.
Some faction-related quests: An Ear to the Ground, Arizona Scavenger, Defacing the Humble Stone, Tags of Our Fallen.
Access Powers) - I consider these complete when the reward is acquired, regardless of method.
The rewards of some unmarked quests are able to be acquired without following the particular quest steps (e.g.
Complete all unmarked quests with some exceptions:.
Fame/Infamy triggered side quests including Beware the Wrath of Caesar!, Caesar's Favor, Caesar's Foe, Caesar's Hire, Don't Tread on the Bear! and Emergency Radio.
Choose Eyesight to the Blind or Tend to Your Business.
Choose Beyond the Beef (certain endings) or Pheeble Will and Beyond the Beef (other endings).
Choose Heartache by the Number or Birds of a Feather.
Choose Ghost Town Gunfight or Run Goodsprings Run.
Complete all side quests, with possible exceptions below:.